Publications

Below are selected publications with the people from the Accili lab in bold. For a more complete and regularly updated view, see Eric’s papers in Pubmed here and in Google Scholar here.

I. Putrenko, R. Yip, S.K.W. Schwarz, E.A. Accili. Cation and voltage dependence of lidocaine inhibition of the hyperpolarization-activated cyclic nucleotide-gated HCN1 channel. Scientific Reports, in press, 2017. 

A.P Hegle, C. A. Frank, A. Berndt, M. Klose, D.W. Allan, E.A. Accili. The Ih channel gene promotes synaptic transmission and coordinated movement in Drosophila melanogaster. Frontiers in Molecular Neuroscience, 10, 41, 2017. doi: 10.3389/fnmol.2017.00041

L. Ng, I. Putrenko, V. Baronas, F. Van Petegem, E.A. AcciliCyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening. Structure, August 2016. doi: 10.1016/j.str.2016.06.024.

M. Akimoto, Z. Zhang, S. Boulton, R. Selvaratnam, B. VanSchouwen,
M. Gloyd, E.A. Accili, O.F. Lange, G. Melacini. A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP. Journal of Biological Chemistry, 289, 22205-20, 2014. doi: 10.1074/jbc.M114.572164

C.J. Peters, D. Fedida, E.A. Accili. Allosteric coupling of the inner activation gate to the outer pore of a potassium channel. Scientific Reports, 2013. doi:10.1038/srep03025

V. Macri, D. Angoli, E.A. Accili. Architecture of the HCN selectivity filter and control of cation permeation. Scientific Reports, 2012. doi:10.1038/srep00894

H.A. Jackson, A. Hegle, H. Nazzari, T. Jegla, E.A. Accili. Asymmetric divergence in structure and function of HCN duplicates in Ciona intestinalis. PLoS One, 2012. doi: 10.1371/journal.pone.0047590

G.M. Whitaker, F.C. Lynn, C. Fulton, C.H. McIntosh, E.A. Accili. Regulation of GIP and GLP1 receptor cell surface expression by N-glycosylation and receptor heteromerization. PLoS One 7(3), e32675, 2012. doi:10.1371/journal.pone.0032675

S.S. Chow, F. Van Petegem, E.A. Accili. Energetics of cAMP binding to HCN channels reveals negative cooperativity. Journal of Biological Chemistry, 287, 600-6,2012. doi:10.1074/jbc.M111.269563                                   

C.J. Peters, D. Werry, H.S. Gill, E.A. Accili, D. Fedida. Mechanism of accelerated current decay caused by an episodic ataxia type-1 associated mutant in a potassium channel pore. Journal of Neuroscience 31, 17449-59, 2011. doi: 10.1523/JNEUROSCI.2940-11.2011.

A.P. Hegle, H. Nazzari, A. Roth, D. Angoli, E.A. Accili. Evolutionary emergence of N-glycosylation as a variable promoter of HCN channel surface expression. American Journal of Physiology – Cell Physiology 298, C1066-76, 2010. DOI: 10.1152/ajpcell.00389.2009

C.J. Peters, M. Vaid, A. Horne, D. Fedida, E.A. Accili. The molecular basis for the actions of Kvb1.2 on the opening and closing of the Kv1.2 delayed rectifier channel. Channels 3, 314-22, 2009.

C.J. Peters, S. Chow, H. Nazzari, D. Angoli, F.S. Cayabyab, E.A. Accili. In situ co-distribution and functional interactions of SAP97 with sinoatrial isoforms of HCN channels. Journal of Molecular and Cellular Cardiology 46, 636-43, 2009.

V. Macri, H. Nazzari, E. McDonald, E.A. Accili. Alanine scanning of the S6 segment reveals a unique and cyclic AMP sensitive association between the pore and voltage-dependent opening in HCN. Journal of Biological Chemistry 284, 15659-15667, 2009. doi: 10.1074/jbc.M809164200

M. Demos, V. Macri, K. Farrell, T. Nelson, K. Chapman, E.A. Accili, L. Armstrong. A Novel KCNA1 Mutation Associated with Global Delay and Persistent Cerebellar Dysfunction. Movement Disorders 24, 778-82, 2009.

H. Nazzari, D. Angoli, S. Chow, G. Whitaker, L. Leclair, E. MacDonald, V. Macri, K. Zahynacz, V. Walker, E.A. Accili.  Regulation of cell surface expression of functional pacemaker channels by a motif in the B-helix of the cyclic nucleotide-binding domain. American Journal of Physiology – Cell Physiology 295, C642-52, 2008. DOI:10.1152/ajpcell.00062.2008

H. Jackson, E.A. Accili. Evolutionary analyses of KCNQ1 and HERG voltage-gated potassium channel sequences reveal location-specific susceptibility and augmented chemical severities of arrhythmogenic mutations. BMC Evolutionary Biology 8, 188, 2008. doi: 10.1186/1471-2148-8-188

D. Fedida, S. Rezazadeh, J. Eldstrom, R. Rupp, Z. Dyer, G. Tibbits, E. Accili, B. Casey, S. Sanatani, L. Arbour. A KCNQ1 V205M missense mutation causes a high rate of long QT syndrome in a First Nations community of northern British Columbia: a community-based approach to understanding the impact. Genetics Medicine 10, 545-50, 2008.

Y. Qu, G. M. Whitaker, L. Hove-Madsen, G.F Tibbits, E.A. Accili. Hyperpolarization-activated Cyclic Nucleotide-modulated ‘HCN’ channels confer regular and faster rhythmicity to beating mouse embryonic stem cells. Journal of Physiology 586, 701-16, 2008. DOI: 10.1113/jphysiol.2007.144329

G.M. Whitaker, D. Angoli, H. Nazzari, R. Shigemoto, E.A. Accili. HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels. Journal of Biological Chemistry 282, 22900-9, 2007. doi: 10.1074/jbc.M610978200

H.J. Jackson, C.R. Marshal, E.A .Accili. Evolution and structural diversification of Hyperpolarization-activated Cyclic Nucleotide-gated genes. Physiological Genomics 29, 231-45, 2007. DOI: 10.1152/physiolgenomics.00142.2006

V.S. Macri, E.A. Accili. Structural elements of slow and fast gating in hyperpolarization-activated cyclic nucleotide-gated channels. Journal of Biological Chemistry 279, 16832 – 16846, 2004. doi: 10.1074/jbc.M400518200

C. Proenza, N .Tran, D. Angoli, K. Zahynacz, E.A. Accili. Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of HCN channels. Journal of Biological Chemistry 277 29634 – 29642, 2002. doi: 10.1074/jbc.M200504200

C. Proenza, D. Angoli, E.  Agranovich, V. Macri, E.A. Accili. Pacemaker channels produce an instantaneous current. Journal of Biological Chemistry 277, 5109 – 5109, 2002. doi: 10.1074/jbc.M106974200

N. Tran, C. Proenza, V.S. Macri, F. Petigara, E. Sloan, S. Samler, E.A. Accili. A conserved domain in the NH2 terminus important for assembly and functional expression of pacemaker channels. 2002. Journal of Biological Chemistry 277, 43588 – 43592, 2002. doi: 10.1074/jbc.M208477200

V. Macri, C. Proenza, E. Agranovich, D. Angoli, E.A. Accili. Separable gating mechanisms in a mammalian pacemaker channel. Journal of Biological Chemistry 277, 35939 – 35946, 2002.

E.A. Accili, C. Proenza, M. Baruscotti, D. DiFrancesco. From funny current to HCN channels: 20 years of excitation.  Physiology 17, 32-37, 2002.